Though the first two offered seemingly endless dialogue choices and character interaction, apparently Mass Effect 3 will dwarf them both.
The original Mass Effect reportedly had around 20,000 lines of spoken dialogue, and the second game had about 25,000.
Mass Effect 3 will apparently dwarf both those games, weighing in with a massive 40,000 lines of dialogue. Those of you who like interacting with the side characters of the ME universe should be very happy about this news.
A fan tweeted concerns about the level of Shepherd's voice volume at an audio designer on the game who replied, "We do our best to keep consistency but it’s tough with 40,000 lines!”