Ken Levine has said Irrational is experimenting with different things at the moment with BioShock Infnite, but there' no guarantee it will contain multiplayer.
Speaking with Kotaku at gamescom, Levine said the team is not interested in multiplayer unless it brings something new to the table; otherwise, players will just go back to playing Halo or CoD.
"Here's what I have to say about multiplayer - it's what we said about BioShock 1: 'We have not made any determinations about multiplayer'," said Levine.
"I will say that we experiment with things, but for us we are never interested in making a multiplayer mode you could just play in some other game. Because, A) that's not creatively interesting and B), financially, you're wasting your time. They're going to go play Halo. They're going to go play Call of Duty.
"If we do something new — if we do something like Left 4 Dead that has something new to say — people will come to your game. If you don't, don't waste your time."
"You're not much of a game designer if you can't draw lessons out of A) good games and bad games and B) games that are not really applicable to what you are doing. You need to look past the surface."