Skyrim players have reported issues with the PS3 version once 5-6MB of stored save data is surpassed, which is apparently causing lag and the inability to interact with NPCs.
According to various forum posts, the issue isn’tt caused by having too many manual game saves, as one save slot can cause the issue as well, since the longer the game is played the larger the stored save file becomes.
Until a fix is issued by Bethesda, which has been working on a patch for various issues on all platforms, users on the forum suggest turning off the autosave feature, and restarting PS3. The later of which seems to help for a few hours at least.
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