Once you've dealt with all that the AG Center has to offer, it's time to see if there's anything you can save at Highpool.
Note: This walkthrough covers Highpool if you choose to save the AG Center first. If you choose to go to Highpool first, you can find that walkthrough here.
Wasteland 2 guide: the destruction of Highpool
Once you enter Highpool follow the railroad tracks to the busted car. Get into position before fighting the lizard enemies. Once they're dealt with, head north to the fence but be careful of the traps on the ground. Use Perception to find them and Demolition skills to disarm. Use Brute Force or attack the fence to get inside the perimeter.
Without alerting the Wreckers, get your team set up for combat and proceed to kill. Once clear, go up the path and again keep an eye out for mines. Move through the gap in the fence and get to the gate in the north corner. Use Perception and you'll see it's booby trapped so use Demolition again to disarm it. Use Lockpicking to open the gate, check for traps and grab the box.
Now go southwest towards the dead bodies and fight another group of Wreckers. Get inside the building that the Wreckers were guarding once you've killed them all.
Grab the chest and continue through the house until you find Sean, the leader of Highpool. He'll be talking with Jackhammer, who commands the Wreckers. Kill Jackhammer and her crew and talk to Sean, chosing the "camp" conversation tree to get a side quest. Now go back outside.
Go up the north path between two cars and you'll arrive in the city. Past the guardhouse, go up the hill to the radio tower. Kill any enemies around here and take the chest they are guarding, then grab the loot from the chest (check for traps!) and examine the radio tower. It's broken, so call Ranger HQ for further instructions.
You're required to find a town called Damonta, east of the old prison. Make sure you've cleaned up any loot and go back to the World Map.