Story will include scenes where "science meets magic" says lead writer.
Titanfall 2 will feature a single-player campaign when it's released on "all platforms" according to lead writer Jesse Stern.
The original game was criticised at release for being multiplayer only and exclusive to Microsoft's Xbox One console.
In a new interview with Forbes, Stern also reveals that developer Respawn is hoping to create a spin-off TV show.
"One of the shortcomings of the first game was we just did not have the mechanism to tell everyone ‘here’s who you are, here’s where you are and who’s around you.’ We knew all the answers, we just could not deliver it," said Stern of the storyline.
"So we are doing our best to deliver a vision of grand global colonial warfare retelling the story of the American Revolution and the American Civil War in space. We imagined the next generation of immigrants moving out to the new frontier of an inhabitable planet. Rather than taking a traditional sci-fi approach to that we wanted to look at how that would happen practically, what the ships would look like and with machines that were designed for excavation and construction, demolition and working the land, and what happens when they are turned into instruments of war.
"What inspires us is the junction of technological advancement with the inevitability of conflict and war and what the next war might look like. In Titanfall 2 there will be a lot of [scenes] where science meets magic, but keeping it grounded and dirty and human and real."
Titanfall is expected sometime before March 2017, according to publisher EA.