According to this, a piece of concept art and first details of shooter sequel Prey 2 have been revealed by Radar Group, the "the IP incubator" firm set up by 3D Realms' boss Scott Miller.
"This time, abandoned and framed for the disappearance of his family, Tommy escapes an Earth that no longer wants him for a future that cannot survive without him," read the description on Radar Group's site.
Prey 2 is listed for release on PC and Xbox 360. Or rather it was listed: Radar Group's site seems to have vanished. Someone must have pushed the wrong button, or something.