Konami is billing the Wii version of PES 2008 as "the future of the football genre" by utilising the Wiimote and Nunchuck to be able to control multiple players on the field. Sounds natty.
According to this, the Nunchuck is used to move the player with the ball, while the Wiimote picks out other players and send them on runs or let them receive passes via a drag system. Up the 16 Miis can be used in the game, as previously known. Take a look at the release for a ton of other information.