There are plenty of weird and wonderful Stranger missions to find throughout Red Dead Redemption 2 and for this quest, you’re on the lookout for a man in a striped suit
You’ll need to have started Chapter 3 before you can access this mission, so just keep playing until you reach Rhodes. You’ll find this gent at the end of the main street.
He’ll explain that he’s a doctor and some bandits ran off with his wagon. Being an honourable man, you agree to retrieve the wagon and its contents. Head back down the street and a second man will approach you and tell you that he heard the thieves say which direction they were heading in.
Where to find the doctor’s wagon
Your map will update with a marker near Macomb’s End, which is near the Y in Lemoyne on the map. Make sure you bring lots of ammo and that your Dead Eye meter is full as you’re in for quite a fight.
Take care of all the enemies and you’ll spot the horse-drawn wagon behind some houses. Take the wagon back to the doctor, but be careful about which route you take. This area is quite swampy and straying off the path could mean you lose the horse and wagon.
You’ll reach a crossroad where two more men will try and kill you, so take them down before pressing on. Return to the doctor who’ll give you a recipe for a new tonic recipe for your troubles.