Little Mac from Punch Out!! should know better than to hit girls, even if they are total badasses like Samus Aran. Still when you enter the Smash Bros. ring, anything goes. Girl or not.
Check out the following Super Smash Bros. Wii U screenshots below, courtesy of Siliconera.
Super Smash Bros. 3DS is due in October, and the Wii U is out sometime during the holidays.